An Autopsy Case of Amyotrophic Lateral Sclerosis with
Neuroinflammatory change

J Korean Neurol Assoc > Volume 30(2); 2012 > Article

Journal of the Korean Neurological Association 2012;30(2): 128-131.

부검에서 신경염증 변화를 확인한 근위축측삭경화증 환자

하승현, 백원기 김현영 노민영 황세진 a 김승현

한양대학교 의과대학 신경과학교실, 해부세포생물학교실 a

An Autopsy Case of Amyotrophic Lateral Sclerosis with Neuroinflammatory change

Seung Hyun Ha

Departments of Neurology and Anatomy and Cell Biology , Hanyang University College of Medicine, Seoul, Korea

Abstract

Neuroinflammation such as reactive gliosis and microglial activations are important pathological findings of ALS. We present a first autopsy case of ALS in Korea related with neuroinflammatory change. A 67-year-old ALS patient suddenly expired due to accidental head trauma. Gross autopsy finding showed marked atrophic change in spinal cord. Pathological finding include a marked loss of motor neurons, reactive gliosis and microglial infiltrations. These findings suggest neuroinflammation may play a role in pathogenesis of ALS. Key Words: Amyotrophic lateral sclerosis, Autopsy, Neuroinflammation