| 신경병 통증에 대한 국제통증연구학회 지침: 2015년과 2025년의 체계적 문헌 고찰 및 메타분석 비교 |
| 최교민1, 김경민2, 김병수3, 김희진4, 김승우2, 백경원5, 석진명6, 선우준상7, 송인욱8, 우호걸9, 이익성9, 정진만10, 최윤호11, 양광익12, 대한신경과학회 진료지침위원회 |
1건국대학교병원 신경과
2연세대학교 의과대학 신경과학교실
3이화여자대학교 의과대학 이대목동병원 신경과
4한양대학교 의과대학 신경과학교실
5고려대학교안암병원 신경과
6이화여자대학교 의과대학 이대서울병원 신경과
7강북삼성병원 신경과g강북삼성병원 신경과
8가톨릭대학교 의과대학 인천성모병원 신경과
9경희대학교 의과대학 경희대학교병원 신경과
10중앙병원 신경과
11고려대학교 의과대학 고려대학교안산 병원 신경과
12순천향대학교 의과대학 순천향대학교천안병원 신경과 |
| The Recommendation of the Neuropathic Pain Special Interesting Group of the International Association for the Study of Pain: A Comparison of Systematic Reviews and Meta-analyses between 2015 and 2025 |
| Kyomin Choi MD, PhD1, Kyung Min Kim MD, PhD2, Byung-Su Kim MD, PhD3, Hee-Jin Kim MD, PhD4, Seung Woo Kim MD, PhD2, Kyoungwon Baik MD, PhD5, Jin Myoung Seok MD, PhD6, Jun-Sang Sunwoo MD, PhD7, In-Uk Song MD, PhD8, Ho Geol Woo MD, PhD9, Eek-Sung Lee MD, PhD9, Jin-Man Jung MD, PhD10, Yun Ho Choi MD, PhD11, Kwang Ik Yang MD, PhD12, On Behalf of the Clinical Practice Guideline Committee of Korean Neurological Association |
1Department of Neurology, Konkuk University Medical Center, Seoul, Korea
2Department of Neurology, Yonsei University College of Medicine, Seoul, Korea
3Department of Neurology, Ewha Womans University Mokdong Hospital, Ewha Womans University College of Medicine, Seoul, Korea
4Department of Neurology, Hanyang University College of Medicine, Seoul, Korea
5Department of Neurology, Korea University Anam Hospital, Seoul, Korea
6Department of Neurology, Ewha Womans University Seoul Hospital, Ewha Womans University College of Medicine, Seoul, Korea
7Department of Neurology, Kangbuk Samsung hospital, Seoul, Korea
8Department of Neurology, Incheon St. Mary’s Hospital, College of Medicine, Catholic University of Korea, Seoul, Korea
9Department of Neurology, Kyung Hee University Hospital, Kyung Hee University College of Medicine, Seoul, Korea
10Department of Neurology, Jungang Hospital, Jeju, Korea
11Department of Neurology, Korea University Ansan Hospital, Korea University College of Medicine, Ansan, Korea
12Department of Neurology, Soonchunhyang University Cheonan Hospital, Soonchunhyang University College of Medicine, Cheonan, Korea |
Corresponding Author:
Kwang Ik Yang ,Tel: +82-41-570-3823, Fax: +82-41-579-9021, Email: neurofan@schmc.ac.kr
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| *These authors contributed equally to this work |
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Received: November 30, 2025 Revised: January 7, 2026 Accepted: January 7, 2026 Published online: February 1, 2026 |
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| Abstract |
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Neuropathic pain markedly impairs quality of life and imposes a substantial socioeconomic burden, while available treatments often provide only partial relief and are limited by safety concerns. The Neuropathic Pain Special Interest Group of the International Association for the Study of Pain (NeuPSIG-IASP) first published pharmacologic recommendations in 2007, followed by a major update in 2015 and a new guideline in 2025. This narrative review specifically compares the 2015 and 2025 NeuPSIG-IASP guidelines, outlining key methodological changes and therapeutic shifts. The 2025 guideline is based on a larger, more rigorous meta-analysis, maintains α2δ-ligands (adds mirogabalin), serotonin-noradrenaline reuptake inhibitors, and tricyclic antidepressants as first-line drugs, downgrades tramadol into the opioid third-line group. It also introduces high-frequency motor-cortex repetitive transcranial magnetic stimulation as a weakly recommended third-line option and discusses implications for Korean clinical practice. |
| Key Words:
Neuralgia | Anticonvulsants | Analgesics | opioid | Transcranial magnetic stimulation |
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