| 이상운동질환 환자에서의 소화기계 증상에 대한 관리: 파킨슨병을 중심으로 |
| 이정윤1, 김경민2, 김병수3, 김승우2, 김희진4, 백경원5, 석진명6, 선우준상7, 송인욱8, 우호걸9, 이익성10, 정진만11, 최교민12, 최윤호8, 고성범1, 양광익13, 대한신경과학회 진료지침위원회 |
1고려대학교구로병원 신경과
2연세대학교 의과대학 신경과학교실
3이화여자대학교 의과대학 이대목동병원 신경과
4한양대학교 의과대학 신경과학교실
5고려대학교안암병원 신경과
6이화여자대학교 의과대학 이대서울병원 신경과
7강북삼성병원 신경과
8가톨릭대학교 의과대학 인천성모병원 신경과
9경희대학교 의과대학 경희대학교병원 신경과
10중앙병원 신경과
11고려대학교 의과대학 고려대학교안산병원 신경과
12건국대학교병원 신경과
13순천향대학교 의과대학 순천향대학교천안병원 신경과 |
| Management of Gastrointestinal Symptoms in Patients with Movement Disorders: Focusing on Parkinson's Disease |
| Jungyeun Lee MD1, Kyung Min Kim MD, PhD2, Byung-Su Kim MD, PhD3, Seung Woo Kim MD, PhD2, Hee-Jin Kim MD, PhD4, Kyoungwon Baik MD, PhD5, Jin Myoung Seok MD, PhD6, Jun-Sang Sunwoo MD, PhD7, In-Uk Song MD, PhD8, Ho Geol Woo MD, PhD9, Eek-Sung Lee MD, PhD10, Jin-Man Jung MD, PhD11, Kyomin Choi MD, PhD12, Yun Ho Choi MD8, Seong-Beom Koh MD, PhD1, Kwang Ik Yang MD, PhD13, on behalf of the Clinical Practice Guideline of Korean Neurological Association |
1Department of Neurology, Korea University Guro Hospital, Seoul, Korea
2Department of Neurology, Yonsei University College of Medicine, Seoul, Korea
3Department of Neurology, Ewha Womans University Mokdong Hospital, Ewha Womans Univerrsity College of Medicine, Seoul, Korea
4Department of Neurology, Hanyang University College of Medicine, Seoul, Korea
5Department of Neurology, Korea University Anam Hospital, Seoul, Korea
6Department of Neurology, Ewha Womans University Seoul Hospital, Ewha Womans Univerrsity College of Medicine, Seoul, Korea
7Department of Neurology, Kangbuk Samsung Hospital, Seoul, Korea
8Department of Neurology, Incheon St. Mary’s Hospital, College of Medicine, The Catholic University, Seoul, Korea
9Department of Neurology, Kyung Hee University Hospital, Kyung Hee University College of Medicine, Seoul, Korea
10Department of Neurology, Jungang Hospital, Jeju, Korea
11Department of Neurology, Korea University Ansan Hospital, Korea University College of Medicine, Ansan, Korea
12Department of Neurology, Konkuk University Medical Center, Seoul, Korea
13Department of Neurology, Soonchunhyang University Cheonan Hospital, Soonchunhyang University College of Medicine, Cheonan, Korea |
Corresponding Author:
Seong-Beom Koh ,Tel: +82-2-2626-3169, Fax: +82-8-2626-2249, Email: parkinson@korea.ac.kr
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Received: August 25, 2025 Revised: September 10, 2025 Accepted: September 10, 2025 Published online: November 1, 2025 |
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| Abstract |
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Parkinson's disease (PD) is the second most common neurodegenerative disease after Alzheimer's disease. While PD is typically characterized by motor symptoms such as bradykinesia, tremor, rigidity, postural instability, and gait disturbances, patients frequently present numerous non-motor symptoms, including gastrointestinal manifestations. These gastrointestinal symptoms may be fundamentally related to alpha-synuclein pathology, and dopaminergic treatments may further contribute to reduced gastrointestinal motility. Gastrointestinal symptoms can occur before the diagnosis of PD and at any stage during the disease course, affecting the gastrointestinal tract from the oral cavity to the anus. If left untreated, gastrointestinal problems can impair medication absorption, leading to motor fluctuations and potentially causing complications such as malnutrition and aspiration pneumonia, which may be life-threatening. Therefore, clinicians should not overlook gastrointestinal symptoms in PD patients. Gastrointestinal symptoms in PD can manifest diversely throughout the entire disease course, requiring healthcare providers to recognize these symptoms and provide individualized management. Since current treatments for PD-related gastrointestinal symptoms are largely derived from data in non-PD patients, future research and clinical guideline development in this field are required for establishing evidence-based care protocols. |
| Key Words:
Parkinson disease | Constipation | Gastroparesis | Sialorrhea | Brain-gut axis |
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