| 신경퇴행질환에 대한 비침습뇌자극술의 임상적 적용 |
| 송인욱1, 김경민2, 김병수3, 김승우2, 김희진4, 백경원5, 석진명6, 선우준상7, 우호걸8, 이익성9, 정진만10, 최교민11, 최윤호1, 양광익6, 대한신경과학회 진료지침위원회 |
1가톨릭대학교 의과대학 인천성모병원 신경과
2연세대학교 의과대학 신경과학교실
3이화여자대학교 의과대학 이대목동병원 신경과
4한양대학교 의과대학 신경과학교실
5고려대학교 안암병원 신경과
6순천향대학교 의과대학 천안병원 신경과
7강북삼성병원 신경과
8경희대학교 의과대학 경희대학교병원 신경과
9중앙병원 신경과
10고려대학교 안산병원 신경과
11건국대학교병원 신경과 |
| Clinical Application of Non-invasive Brain Stimulation for Neurodegenerative Disease |
| In-Uk Song MD, PhD1, Kyung Min Kim MD, PhD2, Byung-Su Kim MD, PhD3, Seung Woo Kim MD, PhD2, Hee-Jin Kim MD, PhD4, Kyoungwon Baik MD, PhD5, Jin Myoung Seok MD, PhD6, Jun-Sang Sunwoo MD, PhD7, Ho Geol Woo MD, PhD8, Eek-Sung Lee MD, PhD9, Jin-Man Jung MD, PhD10, Kyomin Choi MD, PhD11, Yun Ho Choi MD, PhD1, Kwang Ik Yang MD, PhD6, on behalf of the Clinical Practice Guideline Committee of Korean Neurological Association |
1Department of Neurology, Incheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea
2Department of Neurology, Yonsei University College of Medicine, Seoul, Korea
3Department of Neurology, Ewha Womans University Mokdong Hospital, Ewha Womans University College of Medicine, Seoul, Korea
4Department of Neurology, College of Medicine, Hanyang University, Seoul, Korea
5Department of Neurology, Korea University Anam Hospital, Seoul, Korea
6Department of Neurology, Soonchunhyang University Cheonan Hospital, Soonchunhyang University College of Medicine, Cheonan, Korea
7Department of Neurology, Kangbuk Samsung Hospital, Seoul, Korea
8Department of Neurology, Kyung Hee University Hospital, Kyung Hee University College of Medicine, Seoul, Korea
9Department of Neurology, Jungang Hospital, Jeju, Korea
10Department of Neurology, Korea University Ansan Hospital, Ansan, Korea
11Department of Neurology, Konkuk University Medical Center, Seoul, Korea |
Corresponding Author:
In-Uk Song ,Tel: +82-32-280-5010, Fax: +82-32-280-5244, Email: siuysiuy@naver.com
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Received: June 4, 2025 Revised: July 4, 2025 Accepted: July 4, 2025 Published online: August 1, 2025 |
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| Abstract |
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Neurodegenerative diseases, such as Alzheimer's disease (AD) and Parkinson's disease (PD), remain major challenges in clinical neurology, as no definitive cure exists. Non-invasive brain stimulation (NIBS) techniques, including repetitive transcranial magnetic stimulation (rTMS), transcranial direct current stimulation (tDCS), and low-intensity focused ultrasound (LIFU), have emerged as promising therapeutic approaches for modulating cortical excitability and promoting neuroplasticity. rTMS appears to promote synaptic plasticity and increase regional cerebral blood flow, which may contribute to improved memory and executive function. tDCS also has demonstrated potential in enhancing cognitive abilities in AD by modulating cortical excitability via weak direct currents. LIFU, a novel and less explored NIBS method, has shown promise in preclinical and early clinical studies for neurodegenerative diseases. Recent findings suggest that LIFU may enhance cognitive function, facilitate neuroplasticity, and temporarily open the blood-brain barrier to improve drug delivery in AD. In PD, NIBS techniques have been explored to alleviate motor symptoms and improve dopaminergic function. rTMS applied to the motor cortex and supplementary motor area has been associated with improved motor performance, while tDCS has shown potential for enhancing motor functions. LIFU is under investigation for its ability to modulate deep brain structures which plays a key role in PD pathophysiology. This review aims to analyze recent advancements in NIBS applications for AD and PD, highlighting their potential clinical benefits and future directions in neurodegenerative disease management. |
| Key Words:
Non-invasive brain stimulation | Alzheimer disease | Parkinson disease |
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