The Long-term Incidence of Recurrent Stroke: Single Hospital-based Cohort Study

J Korean Neurol Assoc > Volume 27(2); 2009 > Article

Journal of the Korean Neurological Association 2009;27(2): 110-115.

일개 병원기반 코호트에서 관찰한 장기간의 뇌졸중 재발률

고영채, 박정현 김욱주 양미화 권오기a 오창완a 정철규b 백남종c 한문구 배희준

분당서울대학교병원 뇌졸중센터 신경과, 신경외과a, 영상의학과b, 재활의학과c

The Long-term Incidence of Recurrent Stroke: Single Hospital-based Cohort Study

Youngchai Ko

Departments of Neurology, Neurosurgerya, Radiologyb, and Rehabilitation Medicinec, Seoul National University College of Medicine, Stroke center, Seoul National University Bundang Hospital, Seoul, Korea

Abstract

Background: Recurrent stroke is a major cause of morbidity and mortality among stroke survivors. However, studies of the long-term prognosis after acute stroke are very rare, especially in Asia. This study aimed to provide estimates of recurrent stroke rates by age, gender, and subtype of stroke in an unselected cohort of patients hospitalized to a community-based general hospital due to acute stroke.
Methods: Based on a prospective stroke registry, acute stroke patients were enrolled within 7 days of symptom onset and followed retrospectively or prospectively for up to 3 years. Information was gathered about stroke recurrence and other vascular events. The cumulative risk of recurrent stroke was calculated using the Kaplan-Meier method.
Results: Two-thousand and sixty-eight patients were enrolled in this study. The cumulative risks of stroke recurrence were 2.3%, 5.5%, 8.6%, and 10.0% at 90 days and 1, 2, and 3 years, respectively. The prevalence of stroke recurrence increased with age and the presence of previous stroke history (p<0.001), but not with gender or stroke subtype.
Conclusions: To the best of our knowledge, this is the first cohort study of stroke recurrence in Korea. Its limitation of being a single hospital-based study warrants community- or multicenter-based cohort studies to identify high-risk groups for stroke recurrence. Key Words: Cerebrovascular disorders, Epidemiology, Recurrence, Stroke outcome