J Korean Neurol Assoc > Volume 20(2); 2002 > Article

Journal of the Korean Neurological Association 2002;20(2): 124-128.

"알쯔하이머병 환자에서 아포지단백 E, 콜레스테롤, 그리고 인지 감퇴"

김재민 , 손의주 신상문 오봉주

광주시립정신병원 노인정신과, 광주시립정신병원 신경과

"Apolipoprotein E, Cholesterol, and Cognitive Decline in Patients with Alzheimer s disease"

Jae-Min Kim

"Section of Geriatric Psychiatry, Kwangju City Mental Hospital, Kwangju, Korea Section of Neurology, Kwangju City Mental Hospital, Kwangju, Korea"

Abstract

"Background : The associations of apolipoprotein E (ApoE) genotypes and cholesterol levels with cognitive decline in Alzheimer s disease (AD) are controversial. The aim of this study is to investigate the individual and combined effects of ApoE epsilon 4 allele (ε4) and cholesterol levels on the progression of AD. Methods : ApoE genotypes and fasting serum total cholesterol levels were measured in 79 patients with AD. The associations were investigated between ε4, cholesterol level and decline in cognitive function (Korean version of Mini-Mental State Examination) over one year. Results : No prospective individual and combined associations were found between ε4, cholesterol level and decline of cognitive function. Adjustment for age, gender, education, and functional activities of daily living made little difference to the associations. Conclusions : The cognitive decline of AD might be determined by other factors rather than the impact of ε4 or cholesterol levels.Key Words : Apolipoproteins E, Cholesterol, Alzheimer disease, Cognitive decline"