| 당뇨병 환자에서 뇌간 청각신경 유발전위 잠복기의 연장
- 기질적 ? 또는 대사성 ? |
| 김성민, 권기한, 이병철, 엄근용, 배종석 |
| 한림대학교 신경과학교실 |
| Delayed Central Conduction Time on Brainstem Auditory Evoked Potential Pathway in Diabetic Patients
- Functional Origin? Or Structural Origin? |
| Sung-Min Kim, M.D., Ki-Han Kwon, M.D.
Byung-Chul Lee, M.D., Keun-Yong Um, M.D., Jong-Seok Bae, M.D |
| Department of Neurology
Hallym University College of Medicine
94-200, Youngdungpo-Dong, Youngdungpo-Gu,
Seoul, 150-030, Korea |
|
|
|
|
| Abstract |
Background: It has been well known that absolute and interpeak latencies of brainstem auditory evoked potentials
(BAEP) are usually prolonged in diabetics. However, Its etiology is still controversial. We tried to identify whether the
cause is structural or metabolic in origin by performing BAEP and brain MRI in the diabetic patients.
Methods: BAEP
were performed in both the diabetic patients (DM) group (16 males and 15 females) and the normal control group (25
males and 33 female). A brain MRI was performed in the DM group on those who showed abnormal BAEP and com-pared
the results of BAEP of the DM group with those of the control group.
Results: 7 patients (22.6%) showed abnor-mal
BAEP (male; 6, female; 1, unilateral; 4, bilateral; 3) when abnormal BAEP was defined as being larger than two
and a half standard deviations of the control group BAEP results. Two males of the DM group who showed abnormal
structural lesions of the pons in their brain MRI were not included in the statistical analysis. The remaining 14 diabetic
male patients (mean age: 58.7 ±9.1 years, mean disease duration: 6.1 ±4.7 years, mean hemoglobin (Hb) A1C: 7.7 ±
2.0%) and 15 diabetic female patients (mean age: 60.6 ±10.8 years, mean disease duration: 5.4 ±5.1 years, mean
HgA1C: 7.8 ±2.1%) were stastistically analyzed. Interpeak latencies of I-III, III-V, and I-V were found to be signifi-cantly
prolonged in the DM group. The prolongation of interpeak latencies of I-III and I-V were found to be signifi-cantly
correlated with the disease duration only in the diabetic female patients, but not with age and HbA1c.
Conclusions: These findings suggest that both metabolic derangement and structural lesion contribute to prolonging
the central conduction time on BAEP pathway in diabetics.
J Kor Neurol Ass 17(3):389 ~ 393, 1999
Key Words : Brainstem auditory evoked potential, Diabetes mellitus, Magnetic resonance image |
|
PDF Links
Full text via DOI
Download Citation
