Association of Apolipoprotein E Genotypes with Late-onset Alzheimer's Disease in Korea

J Korean Neurol Assoc > Volume 14(2); 1996 > Article

Journal of the Korean Neurological Association 1996;14(2): 538-542.

한국인에서의 지연발현형 알즈하이머병과 아포지단백 E 유전자형과의 상관관계

이용석*, 나덕렬, 김종원**

삼성의료원 신경과, 임상병리과**, 서을대학교 의과대학 신경과학교실*

Association of Apolipoprotein E Genotypes with Late-onset Alzheimer's Disease in Korea

Yong S. Lee, M.D.*, Duk L. Na, M.D., Jong W. Kim, M.D.**

Departutent of Neurology & Clinicol Pothology**, Samsung Medical Center Department of Neurology, College of Medicine, Seoul National University*

Abstract

Apolipoprotein E-ε4(APOE4) is recently known as a susceptibility gene or risk factor associated with late-onset Alzheimer's disease (AD) . Association between APOE4 and probable AD was determined in Korean population. Twenty patients met the NINCDS-ADRDA probable AD criteria (M:F=7:13, Mean age: 70.1 yr)were compared with 146 controls without dementia (M:F=83:63, Mean age:63.6 yr). APOE genotype was determined by polymerase chain reaction and allele specific hybridization technique. APOE4 allele frequency (0.33 vs. 0.11, p<0.01) and proportion of carriers with APOE4(60% vs. 19%, p<0.01) were significantly increased in patient group. APOE4 genotype is also associated with late-onset sporadic AD in Korean, and APOE genotyping may be useful for differential diagnosis of AD for patients with dementia.