A Study of Clinical Characteristics of Cryptococcal Meningitis ?-Diagnosis  and Treatment in 38 cases-

J Korean Neurol Assoc > Volume 13(2); 1995 > Article

Journal of the Korean Neurological Association 1995;13(2): 298-304.

크립토코크스 뇌막염의 임상특징에 관한 연구 - 38예의 진단 및 ?치료를 중심으로-

김정연, 이준홍, 석승한, 허균

연세대학교 신경과, 아주대학교 신경과

A Study of Clinical Characteristics of Cryptococcal Meningitis ?-Diagnosis and Treatment in 38 cases-

Jeong Yeon Kim, M.D., Joon Hong Lee, M.D., Seung Han Suk, M.D., Kyoon Huh, M.D.

Department of Neurology, College of Medicine, Yonsei University, Department of Neurology, College of Medicine, Ajou University

Abstract

A clinical analysis was carried out in 38 patients with cryptococcal meningitis who were admitted at Severance hospital from January 1983 to June 1993. Age of patients ranged from 3 to 72 years (mean 37.5). The number of patients with underlying disease were 19(50%), which are equal to the number of patients without associated disease. The major presenting symptoms were headache in 36 patients (95%), fever in 26 patients(68%), nausea and vomiting in 20 patients(53%) in that order. The brain imaging findings were abnormal in 21 patients(57%). The antifungal therapy was done; amphotericin B only in 3 patients; amphotericin B and flucytocine in 23 patients; fluconazole only in 5 patients. The therapeutic responses were good in 19 patients(50%). The patients with favorable outcome were younger less having focal deficit, seizure, or associated disease.