The Effect of Carbamazepine-Controlled Release on the Congnitive ?Function

J Korean Neurol Assoc > Volume 13(2); 1995 > Article

Journal of the Korean Neurological Association 1995;13(2): 224-232.

서방형 카르마바제핀의 인지기능에 미치는 영향

김갑진, 김재우, 김상호, 하경민, 이상건

동아대학교 신경과, 서울대학교 신경과

The Effect of Carbamazepine-Controlled Release on the Congnitive ?Function

Kab Jin Kim, M.D., Jae Woo Kim, M.D., Sang Ho Kim, M.D., Kyung Min Ha, M.D., Sang Kun Lee, M.D.

Department of Neurology, College of Medicine, Dong-A University and Seoul National University

Abstract

We evaluated the effect of carbamazepine-controlled release (CR) on the cognitive function. By using monotherapy study, we investigated the effects of carbamazepine on cognitive function in 10 epileptic patients and 17 normal controls. The evaluations were conducted before and one and six months after therapy using neuropsychological batteries(BUSCHKE SELECTIVE REMINDING TEST BSRT, REY OSTERRIETH COMPLEX FIGURE TEST ROCFT, CONCENTRATION ENDURANCE TEST d2 test, REY VISUAL DESIGN LEARNING TEST RVDLT, FINGER TAPPING TEST). In the patients treated with carbamazepine-CR monotherapy, follow up studies were made in one and six months later, respectively. It was found that the cognitive function determined in the three tests(consistent long-term retrieval : one item of BSRT, d2 test, and ROCFT : P 0. 05). The mean anticonvulsant blood levels on the day of cognitive function tests were 6.48mg/ml (SD=l. 87) and 6.53mg /ml (SD=l. 97) in one and six months respectively. This study showed carbamazepine-CR monotherapy had an adverse effect on the cognitive function. Key Words : Carbamazepine-controlled release, Neuropsychological batteries, Cognitive fiunction impairment.