Irreversible Parkinsonism due to Acute Organophosphate Intoxication

J Korean Neurol Assoc > Volume 24(3); 2006 > Article

Journal of the Korean Neurological Association 2006;24(3): 298-300.

급성 유기인제 중독에 의한 비가역적 파킨슨증후군

곽재규, 권석범 정혜원 이현의 정 산 황성희

한림대학교 의과대학 신경과학교실

Irreversible Parkinsonism due to Acute Organophosphate Intoxication

Jae-Gyu Kwak

Department of Neurology, Hallym University College of Medicine, Seoul, Korea

Abstract

Only a few case studies describe reversible parkinsonism after organophosphate poisoning and their brain imagings are found to be normal. However, we experienced chronic, irreversible parkinsonism by acute organophosphate poisoning with bilateral basal ganglia lesions found on a brain MRI. We suggest that brief, large amounts of organophosphate intoxication can produce irreversible parkinsonism according to individual susceptibility and further studies including the investigation of insecticides as an environmental factor of parkinsonism should be done using neuroimagings.KeyWords:Organophosphates, Parkinsonism, Neurotoxins