A Case of Voltage Gated Potassium Channel Antibodies-associated Nonparaneoplastic Limbic Encephalitis

J Korean Neurol Assoc > Volume 24(2); 2006 > Article

Journal of the Korean Neurological Association 2006;24(2): 148-152.

전압의존형칼륨통로 항체와 연관된 비부수종양성 변연계뇌염 1예

원요섭, 김지윤 박형준 박수철 이종두a 최일생

연세대학교 의과대학 신경과교실, 핵의학교실a

A Case of Voltage Gated Potassium Channel Antibodies-associated Nonparaneoplastic Limbic Encephalitis

Yoseob Won, M.D.

Departments of Neurology, Nuclear Medicinea, Yonsei University College of Medicine, Seoul, Korea

Abstract

Limbic encephalitis has been reported usually as an autoimmune complication related to onconeuronal antigen of underlying cancer with poor prognosis. Antibodies reactive with neuronal voltage-gated potassium channels (VGKCs) are recently recognized as a pathogenic cause in nonparaneoplastic limbic encephalitis, which is responsive to immunotherapy. We report a patient who had subacute encephalopathy with clinical and radiographic evidences of limbic encephalitis. The patient was seropositive for VGKC antibodies and resulted in a good prognosis with steroids. This has not yet been reported in Korea.KeyWords:Nonparaneoplastic limbic encephalitis, Voltage gated potassium channel antibody, Immunotherapy