Levosulpiride-induced Parkinsonim

J Korean Neurol Assoc > Volume 21(4); 2003 > Article

Journal of the Korean Neurological Association 2003;21(4): 418-421.

Levosulpiride에 의해 유발된 파킨슨 증후군

김중석 , 고석범 한시령 김영인 이광수

가톨릭대학교 의과대학 신경과학교실

Levosulpiride-induced Parkinsonim

Joong-Seok Kim

Department of Neurology, College of Medicine, The Catholic University of Korea

Abstract

"The present report discusses four cases of chronic renal failure, which developed symptoms of parkinsonism in response to levosulpiride. The temporal relationship between levosulpiride discontinuation and the disappearance of parkinsonism suggests a causal link. In addition, decreased striatal dopamine transporter bindings assessed by [I-123] IPT SPECT were observed in two patients suggesting that a dopamine blocking agent causes the dysfunction of nigrostriatal dopaminergic neurons and tha Key Words: Levosulpiride, Drug-induced parkinsonism, [I-123] IPT SPECT"

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