전방 시상경색에서의 역행성 기억상실 |
오지영 , 권 재철, 진주희, 김 재일, 이 재홍, 최 경규, 박 기덕, 정 용, 나 덕렬 |
성균관대학교 의과대학 삼성서울병원 신경과학교실,이화여자대학교 의과대학 신경과학교실,창원 파티마병원 신경과,아주대학교 의과대학 신경과학교실, 울산대학교 의과대학 신경과학교실 |
Retrograde Amnesia Following Anterior Thalamic Infarction |
Jee-Young Oh, M.D. |
Department of Neurology Samsung Medical Center, School of Medicine, Sungkyunkwan University,Ewha Womans University Hospital, Changwon Fatima Hospital, Ajou University Hospital, Ulsan University College of Medicine |
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Abstract |
"Background : Retrograde amnesia (RA) refers to the failure to recall events that occurred before a brain injury. RA is
known to be associated with brain lesions involving the hippocampus, entorhinal cortex and the frontal lobe. Anterior
thalamic lesion often causes anterograde amnesia but rarely causes RA. The aim of the present study is in two parts .
First, we discuss the neuroanatomical perspectives of RA based on our case with severe RA after a right anterior thala-mic
infarction. Second, we introduce a test for RA termed the “Korean Public Events Recall Test (K-PERT)”, which
was developed based on famous Korean public events from 1966 to 1997. Methods : A 62-year-old woman with tran-sient
RA after a left anterior thalamic infarction 4 years ago presented severe and persistent RA following a right anteri-or
thalamic infarction. We followed up the patient with neuropsychological tests. We also performed the K-PERT on
the patient as well as on 14 women of the same age and education. Results : Neuropsychological tests showed severe
impairment in autobiographical memory with frontal lobe dysfunction. On K-PERT, the normal controls scored 13.7 ±
3.7 in recall and 21.2 ±3.1 in recognition out of a maximum score of 30, whereas the patient obtained only 3/30 and
4/30, respectively. Conclusions : In our case, RA might have resulted from damage to the pathway that retrieves old
memories, which are stored in the frontal lobe. Thus, anterior thalamus might be viewed as the gate of memory engram.
Further studies are needed to elaborate the usefulness of K-PERT as an objective tool for investigating remote memory.Key words : Retrograde amnesia, Thalamus, Infarction, Remote memory" |
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