| 측두엽 간질 환자의 피질 이형성증과 해마 경화증;병리학적으로 이중병소를 가진 환자와 해마 경화증만을 가진 환자의 임상적 특징과 수술 성적 |
| 강석윤, 강중구 ·마효일*·곽규환 ·이정교**·박성혜***·강신광***·이상암 |
| 울산대학교 의과대학 서울중앙병원 신경과,신경외과**,진단병리과***,한림대학교 의과대학 신경과학교실* |
| Cortical Dysplasia and Mesial Temporal Sclerosis in Temporal Lobe Epilepsy Pre-operative Clinical Feature and Surgical Outcome between Patients with Dual Pathology and Patients with Mesial Temporal Sclerosis |
| Suk-Yun Kang, M.D., Joong-Koo Kang, M.D., Hyeo-Il Ma, M.D.*, Kyu-Hwan Kwak, M.D.,
Jung-Kyo Lee, M.D.**, Sung-Hye Park, M.D.***, Shin-Kwang Khang, M.D.***, Sang-Ahm Lee, M.D. |
| Department of Neurology, Neurosurgery**, and Pathology***, Ulsan University,
College of Medicine, Asan Medical Center
Department of Neurology*, Hallym University College of Medicine |
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| Abstract |
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Background : Mesial temporal sclerosis (MTS) is a well-known cause of temporal lobe epilepsy. Coexistence with cortical dysplasia (CD) has been reported, but its role is not well recognized. This study aims to determine whether there is any difference about clinical feature and surgical outcome between patients with MTS and coexistent CD (group 1) and patients with isolated MTS (group 2). Methods : Retrospectively, surgical series of 45 patients (male:22, female:23) diagnosed as temporal lobe epilepsy were reviewed. We excluded patients who had another pathology (e. g., tumor, vascular malformation) except MTS or CD. The pathology, case histories, interictal EEG, and surgical outcome were compared. Results : There was a tendency for group 1 patients to have earlier seizure onset age (10.9±6.35 versus 14.5±6.03, p=0.06) There was no statistically significant difference in the history of febrile convulsions (68.4% versus 53.8%, p>0.16) No statistically significant difference between groups were also found in disease duration, the head trauma/mental retardation history, seizure frequency, interictal EEG, and surgical outcome. Conclusions : CD in MTS appears to have an influence on seizure onset. The relationships among CD, febrile convulsion, and mesial temporal sclerosis must be more investigated. J Korean Neurol Assoc 17(6):810~815, 1999 Key Words : Cortical dysplasia, Temporal lobe epilepsy, Dual pathology and mesial temporal sclerosis, Febrile convulsion, Seizure onset, Surgical outcome |
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