Tc-99m HMPAO SPECT in Olivopontocerebellar Atrophy

J Korean Neurol Assoc > Volume 10(3); 1992 > Article

Journal of the Korean Neurological Association 1992;10(3): 324-330.

Olivopontocerebellar Atrophy 환자에서 단일광자방출 전산화단층촬영술에 관한 연구

이상수, 윤병우,노재규,김상은,이명철

충북대학교 신경과. 서울대학교 신경과, 핵의학.

Tc-99m HMPAO SPECT in Olivopontocerebellar Atrophy

Sang-Soo Lee, M.D., Byung-Woo Yoon, M.D., Jae-Kyu Roh, M.D., Sang-Eun Kim, M.D., Myung-Chul Lee, M.D.

Department of Neurology, College of Medicine, Chungbuk National University, Department of Neurology and Nuclear Medicine, College of Medicine, Seoul National University

Abstract

We studied local cerebral blood flow with Tc-99m HMPAO SPECT in 15 patients with olivopontocerebellar atrophy(OPCA) and 15 age-matched control subjects without neurological desease. The diagnosis of OPCA was based upon the history and physical findings and upon the exclusion of other cerebellar ataxia by means of laboratory investigations. Computed tomographic scan and MRI revealed some degree of atrophy of the cerebellum in most patient with OPCA, and many also had atrophy of the brain stem. SPECT studies in these patients revealed decreased cerebral blood flow in the cerebellum in comparison with the normal control subjects(p<0.001). Two patients with minimal atrophy or no structural changes in the cerebellum also showed decreased perfusion. Tc-99m HMPAO SPECT may be useful as a diagnostic test in patients with OPCA. Some instances suggest that Tc-99m HMPAO SPECT may show abnormal finding earlier than other neuroimaging methods.