Paraplegia following Chemonucleolysis A Case Report and Discussion of Neurotoxicity

J Korean Neurol Assoc > Volume 4(2); 1986 > Article

Journal of the Korean Neurological Association 1986;4(2): 231-234.

화학적 수핵분해 요법후 발생한 하지마비 1예

장대일, 김주한, 김명호

한양대학교 신경과.

Paraplegia following Chemonucleolysis A Case Report and Discussion of Neurotoxicity

Dae-Il Chang, M.D., Ju-Han Kim, M.D., Myung-Ho Kim, M.D.

Department of Neurology, College of Medicine, Hanyang University

Abstract

Chymopapain was discovered by Jensen in 1941, and in 1963 Smith demonstrated the chondrolytic properties of chymopapain. Since then, many patients have been injected with this agent. Although there are evidences of neurotoxicity to chymopapain in animals, adverse effects in humans have rarely been reported. We present a case delayed onset of paraplegia after chymopapain chemonucleolysis and review the neurotoxicities to chymopapain.

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