Clinical Significance of Tumor Markers in A Patient with ?Recurrent CNS Non-Germinomatous Germ Cell Tumor

J Korean Neurol Assoc > Volume 12(2); 1994 > Article

Journal of the Korean Neurological Association 1994;12(2): 329-337.

중추신경계내 재발성 비정상피종성 생식세포종양에서의 종양표지자의 ?임상적 중요성

장대일, 윤성상,정경천

경희대학교 신경과.

Clinical Significance of Tumor Markers in A Patient with ?Recurrent CNS Non-Germinomatous Germ Cell Tumor

Dae-Il Chang M.D., Sung Sang Yoon M.D., Kyung Cheon Chung M.D.

Department of Neurology, Kyung Hee University Hospitol

Abstract

Quantitative serial measurements of Alpha-fetoprotein (a-FP) and Beta-human chorionic gonadotropin (B-HCG) using radioimmunoassay were performed in a patient with recurrent non-germinomatous germ cell tumor (NGGCT) into CNS during radiotherapy and chemotherapy. When the pineal tumor was initially presented, elevated levels of serum a-FP and B-HCG fell dramatically to normal rage after the completion of cranial irradiation (5,060cGy). Three months later, the patient had a rise in serum and CSF tumor markers coincident with recurrence of tumor into lumbal spinal canal. Serum levels were not changed despite of 15 days of whole spine irradiation (2,000cGy) although decreased remarkably 1 month after the completion of radiotherapy (4,230cGy). At the time of relapse in the suprasella area and the cerebellopontine angle, serum and CSF levels rised again. As a result of two courses of chemotherapy the tumor markers fell markedly, but the tumor was spread to other sites into CNS. We conclude serial measurements of a-FP and B-HCG are useful for the diagnosis of the non-germinomatous germ cell tumor into CNS and for monitoring disease activity.