| 알코올과 관련된 신경계 질환: 10년간의 경험 |
| 오세호, 김수연 박경석 박성호 |
| 서울대학교 의과대학 신경과학교실, 분당서울대학교병원 신경과 |
| Alcohol-Related Neurologic Disorders: Ten Years of Experiences |
| Se Ho Oh |
| Department of Neurology, Seoul National University Bundang Hospital, College of Medicine, Seoul National University,
Seoul, Korea |
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| Abstract |
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Alcohol-related disorders are among the most costly health problems worldwide. Ingested alcohol is mainly metabolized
by an oxidative pathway in the liver. Alcohol and its metabolic products (e.g., acetaldehyde and reactive oxygen species)
have toxic effects on multiple organs, especially the nervous system. The diverse mechanisms of alcohol-related
neurologic disorders include the direct toxic effects of alcohol, the alcohol withdrawal effect, nutritional deficiency
secondary to alcoholism, and abnormalities of serum electrolytes and osmolality. We analyzed 156 cases of alcoholrelated
neurologic disorders among admitted patients that had been referred in Korea during the previous 10 years. The
duration of alcohol consumption ranged from 0.5 to 47 years (mean=17.8 years) and the mean amount of alcohol intake
per day was 245.5 g. The 156 patients had the following diseases: Wernicke’s encephalopathy (n=81, 51.9%), peripheral
neuropathy (n=68, 43.6%), delirium tremens (n=59, 37.8%), Rum fit (n=31, 19.9%), pellagra encephalopathy (n=29,
18.6%), Korsakoff’s psychosis (n=22, 14.2%), cerebellar atrophy (n=11, 7.0%), and alcoholic myopathy (n=6, 3.8%). We
report on these cases and review the literature on alcohol-related neurologic disorders. Key Words: Alcohol, Wernicke’s encephalopathy, Alcoholic neuropathy, Pellagra, Marchiafava-Bignami disease,
Alcohol withdrawal syndrome |
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