Olfactory Function and Its Correlation with Cardiac 123I-MIBG in Patients with Parkinson’s Disease and Multiple System Atrophy

J Korean Neurol Assoc > Volume 25(1); 2007 > Article

Journal of the Korean Neurological Association 2007;25(1): 38-43.

파킨슨병과 다계통 위축증 환자들에서 후각기능 및 후각기능과 심장 123I-MIBG섭취율과의 연관성

여승현, 신동훈 김현준a 이필휴

아주대학교 의과대학 신경과학, 이비인후과학교실a

Olfactory Function and Its Correlation with Cardiac 123I-MIBG in Patients with Parkinson’s Disease and Multiple System Atrophy

Seung Hyeon Yeo

Department of Neurology and Otolaryngologya, Ajou University School of Medicine, Suwon, South Korea

Abstract

Background: Tetanus toxin selectively blocks inhibitory synapses in the brainstem as well as the spinal cord. Therefore, in contradiction to Stiff Person syndrome, patients with generalized tetanus usually show abnormal masseter silent periods as well as abnormal F/M amplitude or H/M amplitude ratios. This study aimed to verify the characteristics of electrophysiological findings of generalized tetanus.
Methods: The authors retrospectively studied clinical and electrophysiological characteristics of 7 patients with generalized tetanus, who were admitted to the neurology department of Hallym Medical Center from 1995 to 2005.
Results: All the seven patients showed abnormal masseter silent periods. Three of them showed somewhat improvement in the silent period at follow-up study as trismus was improving. Full NCSs done in two patients did not show any abnormalities except an increased F/M amplitude ratio. One patient with a wound site in his left finger showed an abnormal F/M amplitude ratio only in the right upper extremity without involvement of other extremities. Another patient showed an increased H/M amplitude ratio without an increased F/M amplitude ratio. (In this patient we did not conduct full NCS tests.)
Conclusions: The Masseter silent period could be used as a diagnostic tool and parameter of clinical improvement in patients with generalized tetanus. KeyWords:Olfaction Disorders, Parkinson Disease, 3-Iodobenzylguanidine, Multiple System Atrophy