Two Cases of Invasive Aspergillosis of Sino-nasal Origin

J Korean Neurol Assoc > Volume 18(3); 2000 > Article

Journal of the Korean Neurological Association 2000;18(3): 368-371.

부비동-비강에서 파급된 침입성 아스페르길루스증 2예

류선영 정태익 한시령 김영인 김병기*, 류선영 정태익 한시령 김영인 김병기*

가톨릭대학교 의과대학 신경과학교실,병리학교실*

Two Cases of Invasive Aspergillosis of Sino-nasal Origin

Seon-Young Ryu, M.D., Tae-Ik Chung, M.D., Si-Ryung Han, M.D., Yeong-In Kim, M.D., Bung-Ki Kim, M.D.*

Department of Neurology and Pathology*, College of Medicine, The Catholic University of Korea

Abstract

Cerebral aspergillosis is a rare condition that affects primarily the immunocompromised host. Most of cerebral aspergillosis is developed by hematogenous dissemination from extracranial foci, but aspergillosis of sino-nasal origin rarely affects the CNS. In case 1, we describe a 78 year-old woman presented by intermittent fever and cough, and aki-netic mutism. PNS and brain CT scans showed filling mass in the PNS, extending intracranially with skull base ero-sion. In case 2, a 67 year-old woman who had taken steroid for presumed optic neuritis one month ago was presented with right ophthalmoplegia. Orbit MRI and PNS CT showed well enhanced lesions of right optic canal, cavernous sinus, and anterior aspect of middle cranial fossa with aggressive sinusitis. In both cases, the pathology of PNS showed septate hyphae with branching. They were treated with antifungal agent, with the resection of PNS in case 2, but were expired a month after admission. J Korean Neurol Assoc 18(3):368~371, 2000 Key Words : Aspergillosis, Paranasal sinus diseases, Central nervous system diseases