Serum Lipoprotein(a) as a Risk Factor for Thrombotic Cerebrovascular Disease

J Korean Neurol Assoc > Volume 12(1); 1994 > Article

Journal of the Korean Neurological Association 1994;12(1): 1-9.

혈전성 뇌혈관 질환의 위험 인자로서의 Lipoprotein(a)

노재규, 이영주,김진규

서울대학교 신경과, 임상병리학.

Serum Lipoprotein(a) as a Risk Factor for Thrombotic Cerebrovascular Disease

Jae Kyu Roh, M.D, Young Joo Lee,M.D, Jin Q Kim, M.D.

Department of Neurology,Seoul National University, College of Medicine Department of Clinical Pathology, Seoul National University, College of Medicine

Abstract

The role of lipid and liporotein abnormalities, especially that of liporotein(a) [Lp(a)], in thrombotic cerebrovascular disease(TCVD) is not as clear as in ischemic heart disease(IHD). To evaluate the relationship between lipid profile and TCVD, we measured lipid profiles and Lp(a) levels in patients with TCVD. Forty five patients with TCVD(29 men, 16 women; mean age. 61+10 years) and fifty age and sex-matched healthy controls(35 men, 15 women; mean age, 62+11 years) were examined in this study. The patients who had definite embolic source of cardiac origin and who had history of IHD or evidence of old IHD were excluded. The patients were divided into two subtype groups, the large artery occlusion group(LAT, n=19) and the perforating artery occlusion groupp(PAT, n=26). Lipoprotein profiles and Lp(a) levels were investigated in acute stage of TCVD and at 2 months after the ictus. The mean Lp(a) level decreased at 2 months after the ictus, but the change was not statistically significant. The levels of Lp(a), total cholesterol and triglyceride were significantly higher and the level of apolipoprotein A-I was significalntly lower in in patients with TCVD compaired to control group. In Multivariate analysis, only the level of Lp(a) was significantly higher and the level of apolipoprotein A-I was significantly lower in patients wlth TCVD than those of control group. There was no significant difference of Lp(a) level between subgroups of TCVD and between subgroups divided by absence or presence of other risk factors such as hypertension, diabetes, family history of stroke. We concluded that Lp(a) level may be an independen risk factor in TCVD as well as in IHD. "