The Therapeutic Effect of Drug in Parkinson's Disease

J Korean Neurol Assoc > Volume 7(1); 1989 > Article

Journal of the Korean Neurological Association 1989;7(1): 19-25.

파킨슨병에 있어서 약물치료 효과

최일생, 이명식,이영진,정원영,이성수,김원천

연세대학교 신경과.

The Therapeutic Effect of Drug in Parkinson's Disease

Il-Saing Choi,M.D., Myung-Sik Lee,M.D., Young-Jin Lee,M.D., Won-Young Chung,M.D., Sung-Soo Lee,M.D., Won-Tsen Kim,M.D.

Department of neurology, Yong Dong Severance Hospital, College of Medicine, Yonsei University

Abstract

Two hundred and four patients with Parkinson's disease initially treated wth a combination of levodopa and carbidopa ( Sinement 25-250 ) and / or anticholinergic drugs. All patients responded initially to drug. Sixteen patients(7.8%) had 20 acute central nervous system side effects: 8, dyskinesia: 6, visual hallucination:5, psychosis: and 1, akathisia. The response to treatment usually was stable for the first one and a half to four years of drug therapy. Subsequently, over 50 percent of patients had therapeutic failure among 82 patients with long term drug therapy, fourteen(l7.0%) had 18 side effects: 8, on-off phenomenon: 4. Morning dystonia: 3, dyskinesia:and 3, simultaneous dyskinesia with parkinsonism. None had diphasic dyskinesia or myoclonus. The prognosis of the demented parkinsonian was relatively poor. Two patients died due to pneumonia and ovarian carcinoma.