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레카네맙: 국내 알츠하이머병 치료의 현재와 미래

Lecanemab: Shaping the Present and Future of Alzheimer’s Disease Treatment in Korea

Sung Hoon Kang, MD

레카네맙: 국내 알츠하이머병 치료의 현재와 미래

강성훈
Received June 20, 2025;       Revised July 1, 2025;       Accepted July 1, 2025;
[연관 대한신경과학회지 발표 문헌] DOI: https://doi.org/10.17340/jkna.2021.3.4
jkna-43-3-194i1.tif
Professor Sung Hoon Kang
Audio. Lecanemab: shaping the present and future of Alzheimer’s disease treatment in Korea.
The Alzheimer’s disease treatment lecanemab has garnered significant attention as a groundbreaking therapy since its introduction in Korea in late 2024, due to its ability to intervene in the core amyloid pathology of the disease and slow its progression [1,2]. In this interview, we are joined by Professor Sung Hoon Kang, a dementia specialist at Korea University Guro Hospital, who has extensive clinical experience with lecanemab in real-world Alzheimer’s disease cases. We discuss the drug’s mechanism of action, indications, administration and monitoring strategies, as well as actual patient cases [3-5].
REFERENCES
REFERENCES

1. van Dyck CH, Swanson CJ, Aisen P, Bateman RJ, Chen C, Gee M, et al. Lecanemab in early Alzheimer's disease. N Engl J Med 2023;388:9-21.
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2. Chen C, Katayama S, Lee JH, Lee JY, Nakagawa M, Torii K, et al. Clarity AD: Asian regional analysis of a phase III trial of lecanemab in early Alzheimer's disease. J Prev Alzheimers Dis 2025;12:100160.
[Article] [PubMed] [PMC]
3. Park KH, Kim GH, Kim CH, Koh SH, Moon SY, Park YH, et al. Lecanemab: appropriate use recommendations by Korean Dementia Association. Dement Neurocogn Disord 2024;23:165-187.
[Article] [PubMed] [PMC]
4. Kang SH, Jeong JH, Pyun JM, Kim GH, Park YH, Shim Y, et al. Eligibility for lecanemab treatment in the Republic of Korea: real-world data from memory clinics. J Clin Neurol 2025;21:182-189.
[Article] [PubMed] [PMC]
5. Ashton NJ, Brum WS, Di Molfetta G, Benedet AL, Arslan B, Jonaitis E, et al. Diagnostic accuracy of a plasma phosphorylated Tau 217 immunoassay for Alzheimer disease pathology. JAMA Neurol 2024;81:255-263.
[Article] [PubMed] [PMC]

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