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J Korean Neurol Assoc. 2014;32(4):246-253.
- Association between Baseline Serum Uric Acid Levels with Functional Outcomes at 3 Months after Acute Ischemic Stroke
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So Young Pyun
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Department of Neurology, Asan medical center, University of Ulsan College of Medicine, Seoul, Korea,
Department of Neurology
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, Hallym University College of Medicine, Anyang, Korea
- 급성허혈뇌졸중 환자의 초기 혈중 요산농도와 발병
3개월 후 기능예후와의 연관성
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변소영, 김영은 오미선
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유경호
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김보희
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이은주
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이병철
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울산대학교 의과대학 서울아산병원 신경과, 한림대학교 의과대학 신경과
a
- Abstract
- Background
Currently available data suggests that uric acid (UA) functions as an antioxidant after acute ischemic stroke
(AIS). Nevertheless, the prognostic value of serum UA in AIS is controversial. The aim of this study was to determine the
relationship between UA and functional outcomes after AIS.
Methods
UA levels were analyzed within 48?hours of stroke onset in patients between 2007 and 2012. Mean serum UA
levels were compared between patients with good and poor functional outcomes (modified Rankin Scale [mRS] score,
0-2 versus 3-6, respectively) at 3?months poststroke, and with and without early neurological improvement (ENI, ≥
4-versus <4-point differences on the National Institutes of Health Stroke Scale [NIHSS] score after 7?days).
Results
Serum UA levels differed according to the sex, age, stroke subtype, and presence of diabetes mellitus, smoking,
and atrial fibrillation. Multivariate logistic regression analysis revealed an association between good functional outcome
at 3?months and male gender, young age, history of dyslipidemia, good functional status before stroke (mRS score, 0-2),
and low stroke severity (i.e., NIHSS score) on admission. However, higher serum UA levels were no longer associated
with a good functional outcomes (odds ratio, 1.387; 95% confidence interval, 0.857-2.244; p=0.521). The mean serum UA
levels did not differ significantly between patients with and without ENI.
Conclusions
There was no association between serum UA levels and functional outcomes at 3?months in AIS. Key Words: Cerebral infarction, Cerebrovascular disorders, Uric acid, Outcome assessment, Myocardial infarction
Keywords :
- 초록
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