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J Korean Neurol Assoc. 2014;32(3):168-170.
- Reversible Cerebellar Leukoencephalopathy Associated With Oral
Methotrexate
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Juyoun Lee
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Department of Neurology, Chungnam National University Hospital, Chungnam National University School of Medicine,
Daejeon, Korea
- 메토트렉세이트 경구복용 후 발생한 가역소뇌백질뇌병증
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이주연, 오응석 정성해 손은희 이애영
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충남대학교 의과대학 충남대학교병원 신경과
- Abstract
- Methotrexate (MTX)-induced leukoencephalopathy is the most often reported leukoencephalopathy following
intrathecal or intravenous administration. A 72-year-old woman developed leukoencephalopathy localized to the
cerebellum after treatment with oral MTX at a dose of 15 mg/week for 3 years. She complained of subtle imbalance
during walking and reported having fallen. Her symptoms improved after discontinuation of MTX, and the
leukoencephalopathy resolved. This is therefore a case report of selective cerebellar reversible leukoencephalopathy
associated with oral MTX. Key Words: Leukoencephalopathy, Methotrexate, Cerebellum
Keywords :
- 초록
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