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J Korean Neurol Assoc. 2014;32(2):98-102.
- Logopenic Progressive Aphasia Revealing Positive Cerebrospinal Fluid
Biomarkers for Alzheimer’s Disease
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Hyung-Jun Kim
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Department of Neurology and Anesthesiology
, Soonchunhyang University Hospital, Soonchunhyang University College
of Medicine, Bucheon, Korea
- 알츠하이머병 뇌척수액 생물표지자 양성을 보인
로고페닉진행실어증
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김형준, 김태은 김새로미 채원석
박선아
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순천향대학교 의과대학 순천향대학교 부천병원 신경과, 마취과
- Abstract
- Primary progressive aphasia (PPA) is classified into agrammatic, semantic, and logopenic variants, but differential
diagnosis is often challenging. There is accumulating evidence that the neuropathology of logopenic PPA is distinct from
that of the other types. We report herein a woman with logopenic PPA who was diagnosed by clinical, neuropsychological,
and radiologic data during 2?years of follow-up. Interestingly, her cerebrospinal fluid biomarkers were found to be
similar to those found in Alzheimer’s disease, with a decreased concentration of Aβ42 and an increased concentration of
pTau181 (tTau). Key Words: Biomarker, Cerebrospinal fluid, Logopenic aphasia
Keywords :
- 초록
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