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J Korean Neurol Assoc. 2013;31(3):173-177.
- Decreased Retinal Thickness in Patients With Alzheimer’s Disease
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Bong-hui Kang
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Department of Neurology, Dankook University Medical College, Cheonan, Korea
- 알쯔하이머병 환자에서 감소된 망막두께
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강봉희, 김재일
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단국대학교 의과대학 신경과학교실
- Abstract
- Background
The loss of ganglion cells observed in Alzheimer’s disease (AD) patients might be attributable to a
neurodegenerative process involving the neuroretinal structure. The objective of this study was to determine the retinal
thickness in patients with AD using optical coherence tomography (OCT).
Methods
Neuro-ophthalmologic examinations were performed in eight AD patients and eight age-matched control
subjects. The average thicknesses of the retinal nerve fiber layer (RN리) and the ganglion cell?inner plexiform layer
(GCIPL) were measured using spectral-domain OCT in both subject groups, and the results were compared.
Results
The RNFL was thinner in AD patients than in the age-matched controls (p<0.05), especially at the nasal and
inferior retina, and the GCIPL was also significantly thinner (p<0.05).
Conclusions
The decreased retinal thickness observed in AD patients suggests that OCT can be used as a biological
marker of AD. The findings of this preliminary study suggest that the extent of the reduction in GCIPL and RNFL
thicknesses should be investigated further. Key Words: Alzheimer’s disease, Spectral-domain optical coherence tomography, Retinal nerve fiber layer, Ganglion
cell?inner plexiform layer
Keywords :
- 초록
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