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J Korean Neurol Assoc. 2013;31(3):165-172.
- Influence of 3 Stigmas of Small Vessel Disease on FLAIR Change in
Acute Ischemic Stroke: Case-Control Study
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Dohoung Kim
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Department of Neurology, Seoul National University Bundang Hospital Stroke Center, Seoul National University College
of Medicine, Seongnam, Korea
Department of Radiology
a
, Seoul National University Bundang Hospital Stroke Center, Seoul National University
College of Medicine, Seongnam, Korea
- 급성허혈뇌경색에서 액체감쇠역전회복영상 변화에
소혈관질환의 세 가지 징후가 미치는 영향에 대한
환자-대조군 연구
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김도형, 강지훈 김나영 노원영 장민욱 김범준 한문구 정철규
a
최병세
a
김재형
a
배희준
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서울대학교 의과대학 분당서울대병원 뇌졸중센터 신경과, 영상의학과
a
- Abstract
- Background
Attempts have been made to use the signal changes of fluid-attenuated inversion recovery (FLAIR) MRI as
"a tissue clock," defined as a surrogate marker of the tissue damage resulting from acute ischemic stroke. The evolution of
FLAIR signals after stroke onset has never been fully explained solely by time. The aim of this study was to determine
whether cerebral small-vessel disease (SVD) affects FLAIR changes following acute ischemic stroke.
Methods
Based on data from a prospective stroke registry, consecutive patients who were hospitalized to the stroke
center within 12?hours of stroke onset between January 2004 and May 2011 and had occlusion of the major cerebral
arteries in the anterior circulation, as evidenced by MR angiography, were enrolled. Cases with FLAIR changes and
controls without FLAIR changes were matched according to the time elapsed from stroke onset to MR study.
Results
Among the 130 patients who met the eligibility criteria, 62 (47.7%) had FLAIR changes. The time interval
between stroke onset and MR study differed significantly between those with and without FLAIR changes (5.2?hours vs.
3.0?hours). FLAIR changes were more common among males and smokers. Comparisons between cases and controls
matched on a one-to-one basis did not reveal any difference in the three signs of cerebral SVD: white-matter
hyperintensities, lacunae, and cerebral microbleeds.
Conclusions
This study failed to find any data supporting the hypothesis that cerebral SVD affects FLAIR changes after
acute ischemic stroke. Key Words: Acute stroke, Fluid attenuated inversion recovery, Small-vessel disease
Keywords :
- 초록
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