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J Korean Neurol Assoc. 2012;30(3):182-189.
- Analysis of an Association between Single Nucleotide Polymorphisms
of Vascular Endothelial Growth Factor Gene and Risk of Cerebral
White Matter Lesion
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So-Young Park
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Department of Neurology, CHA University and The Institute for Clinical Research
, Seongnam, Korea
- 혈관내피성장인자유전자 단일뉴클레오티드다형태와
대뇌백질변성 위험성의 연관성분석
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박소영, 김미화 안세아 김남근
a
김옥준 오승헌
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CHA 의과학대학교 신경과학교실, 임상의학연구소
a
- Abstract
- Background
Endothelial dysfunction is suggested to be one of the pathogenesis of cerebral white matter lesion (cWML).
Vascular endothelial growth factor (VEGF) plays a crucial role in angiogenesis and integrity of vascular endothelial cell,
and altered expression of VEGF gene induces vascular diseases including cerebrovascular diseases. The objective of this
study is to investigate whether single nucleotide polymorphism (SNP) of VEGF gene confers an increased risk of cWML.
Methods
Total 337 study subjects without history of stroke were included. The presence and severity of cWML were
measured on fluid-attenuated inversion recovery image. Genotypes of VEGF -2578G>A, -1154G>A, -634G>C and
+936C>T were analyzed.
Results
Among 337 study subjects, cWML was found in 208 patients (62%), and fifty-eight cases (17%) of them had overt
cWML. In univariate analysis, age, female sex and plasma total homocysteine level (tHcyt) were higher in the mild and
overt cWML group than no cWML group (p<0.05). The percentage of previous history of hypertension and the value of
systolic blood pressure were higher in overt cWML group than no cWML group. In univariate and logistic regression
analysis, none of four tested VEGF SNPs was significantly different between control group, mild and overt cWML
groups. There was no difference between plasma tHcyt levels and each VEGF SNPs in control group and cWML groups.
Conclusions
In this study, old age, female sex, hypertension and plasma tHcyt were associated with cWML. However,
we failed to find an association between cWML and VEGF gene polymorphism, which may indicate that genetic
polymorphism of VEGF does not play a direct role in the pathogenesis of cWML. Key Words: Cerebral white matter lesion, Polymorphism, Vascular endothelial growth factor
Keywords :
- 초록
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