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J Korean Neurol Assoc. 2011;29(4):347-351.
- Serial Follow-up of White Matter Connectivity in a Patient with
Progressive Multifocal Leukoencephalopathy Presenting Clinical
Improvement
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Dan-il Chung
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Department of Neurology, College of Medicine, Hanyang University, Seoul, Korea
- 임상적으로 호전된 진행다초점백질뇌병증 환자의
백질 내 해부학적 연결성 추적 관찰
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정단일, 오성일 오경필 백원기 김희진 김승현
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한양대학교 의과대학 신경과학교실
- Abstract
- Progressive multifocal leukoencephalopathy (PML) is a fatal disease that is characterized by progressive demyelination
of the cerebral white matter due to JC viral infection. We report serial magnetic resonance spectroscopy (MRS) and
tractography changes in a patient with PML. After a three-cycle treatment with cidofovir and cytarabine, the patient
exhibited remarkable improvements in motor and cognitive functions. Follow-up MRS and tractography revealed
regeneration of the white-matter fibers. This is the first consecutive neuroimaging study showing improvements in
neurological symptoms using MRS and tractography. Key Words: Progressive multifocal leukoencephalopathy, Magnetic resonance spectroscopy, Tractography
Keywords :
- 초록
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