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J Korean Neurol Assoc. 2011;29(4):291-294.
- Interictal Gastric Motility in Patients with Migraine
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Yu-Ri Jeong
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Departments of Neurology and Internal Medicine
a
, Eulji General Hospital, Eulji University College of Medicine, Seoul,
Korea
- 편두통 환자에서 비두통기 상부위장관 운동장애
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정유리, 황민호 강규식 권오현 박종무 이정주 조윤주
a
김병건
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을지대학교 을지병원 신경과, 내과
a
- Abstract
- Background
Nausea and vomiting are predominant accompanying symptoms of migraine attacks. Although the
underlying mechanism is not yet clear, gastric stasis is assumed to be the main factor. However, few studies have used
direct methods to establish delayed gastric emptying of migraine patients. We compared interictal gastric motility
between migraine patients and normal controls with the aid of gastric scintigraphy.
Methods
The study population comprised patients who had been diagnosed with episodic migraine, according to the
International Classification of Headache Disorders, edition II. The entire study population was completely free of
gastrointestinal symptoms during the headache-free period. Gastric scintigraphy was performed to determine the time
to half emptying (T1/2 ) and the percentage of radioactive material remaining in the stomach (%RMR) at 30, 60, 90, and
120?min.
Results
Twenty-six migraine patients and 12 normal controls were recruited. The mean T1/2 did not differ between the
two groups (101.8 vs 95.2?min; p=0.432). The %RMR values in the stomach at 30, 60, 90, and 120?min also did not differ
significantly between the two groups [87.5% vs 88% (p=0.900), 70.8% vs 71.2% (p=0.950), 54.2% vs 53.3% (p=0.753), and
39.0% vs 37.3% (p=0.583), respectively].
Conclusions
There is no gastric stasis in patients with episodic migraine during headache-free periods. Our results
suggest that the main mechanism underlying the nausea and vomiting in migraine patients is not a gastric stasis in
interictal periods, but rather a central process, as a result of changes occurring in the brainstem during acute migraine
attacks. Key Words: Migraine, Nausea, Vomiting, Gastric stasis, Gastric scintigraphy
Keywords :
- 초록
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