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J Korean Neurol Assoc. 2010;28(3):172-178.
- Neutrophil to Lymphocyte Ratio at Admission: Prognostic Factor in
Patients With Acute Ischemic Stroke
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Jong-Kyu Park
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Department of Neurology, Soonchunhyang University College of Medicine, Cheonan, Korea
Department of Neurology, Seoul Medical Center
a
, Seoul, Korea
- 급성 뇌경색 환자에서 입원시 호중구/림프구 비가
예후에 미치는 영향
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박종규, 오형근 박태환
a
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순천향대학교 의과대학 신경과학교실, 서울의료원 신경과
- Abstract
- Background
Inflammatory mechanisms play an important role in acute brain ischemia, and they contribute to the
functional outcome. The neutrophil-to-lymphocyte ratio (NLR) has recently been described as a predictor of clinical
outcomes in patients with acute coronary syndrome. This study assessed the clinical significance of NLR as a new
predictor of the outcome in patients with acute ischemic stroke.
Methods
The study included 371 patients diagnosed as acute ischemic stroke within 48 hours after the onset. All subjects
were divided into three groups according to tertiles of the NLR in the initial blood test. Functional outcomes were
divided into two groups at 3 months and 1 year after stroke onset: favorable (mRS 0~2) or unfavorable (mRS 3~6).
Results
The proportion of patients with mRS 0~2 (favorable outcome) decreased as the NLR increased from the first
tertile to the third tertile at discharge (74%, 62.9 and 49.2, p<0.001) and at 3?months (74%, 66.9 and 42.7, p<0.001) and 1
year (67.5%, 64.5 and 41.1, p<0.001) after stroke. NLR was higher in patients with an unfavorable outcome than in those
with a favorable outcome (3.88 vs. 2.27 at 3 months, p<0.01; 3.67 vs. 2.31 at 1 year, p<0.001). Multivariate analysis revealed
that the significant predictors of an unfavorable outcome at 3?months were NLR in the highest tertile (OR 2.28, 95% CI
1.13~4.60), age (OR 1.04, 95% CI 1.01~1.07), and NIHSS score (OR 1.27, 95% CI 1.18~1.36) at admission.
Conclusions
NLR at admission can be used as a predictor of functional outcome at 3 months after ischemic stroke. Key Words: Neutrophil-to-Lymphocyte ratio, Prognosis, Ischemic stroke
Keywords :
- 초록
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