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J Korean Neurol Assoc. 2009;27(4):375-383.
- 간질 환자의 우울과 불안: 인구학적 요인 및
간질 관련 요인과의 관계
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Seon-Hee Heo
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Graduate School of Medicine, Gachon University of Medicine and Science,
Department of Neurology, Gachon University Gil Hospitala, Incheon, Korea
- Depression and Anxiety in the Epileptic Patients: the Association With
Demographic and Seizure-Related Variables
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허선희, 박현미
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가천의과학대학교 의학전문대학원, 가천의과학대학교 길병원 신경과학교실a
- Abstract
- Background
Depression and anxiety are common psychiatric symptoms in patients with epilepsy, exerting a profound
negative effect on health-related quality of life. Several issues, however, pertaining to their association with psychosocial,
seizure-related and medication factors, remain controversial. In the present study we have investigated the association of
depression and anxiety with various demographic and seizure-related variables in patients with newly-diagnosed and
chronic epilepsy.
Methods
We investigated 80 patients with epilepsy (46.3% males, mean age 36.1±11.4 years, range 18~64; mean disease
duration, 13.4±12.2 years). Depression and anxiety were assessed in the interictal state with the Beck Depression
Inventory, 21-item version (BDI-21) and the state and trait subscales of the State-Trait Anxiety Inventory (STAI-S and
STAI-T), respectively. The association of depression and anxiety with various variables was investigated using
univariate analyses and multiple linear regression analyses.
Results
Duration of epilepsy, the number of side effects and the number of GABAergic anti-epileptic drugs were
correlated with depression, together accounting for 25.1% of the variation of the BDI-21. The STAI-S index was significantly
associated with occupation status and the number of GABAergic anti-epileptic drugs accounting for 27.4% of the
variation of the STAI-S. Finally, the number of side effects was correlated with trait anxiety.
Conclusions
Our study shows that the duration of epilepsy, occupation status, GABAergic anti-epileptic drugs and the
number of side effects are risk factors for the development of depression and/or anxiety. Key Words: Epilepsy, Depression, Anxiety
Keywords :
- 초록
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