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J Korean Neurol Assoc. 2009;27(4):337-344.
- 백색질변성과 Paraoxonase 유전자 변이
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Byoung-Soo Shin
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Department of Neurology, Chonbuk National University Medical School, Institute for Medical Science, Chonbuk National
University, Chonbuk National University Hospital Research Institute of Clinical Medicine, Jeonju, Korea
- Paraoxonase Polymorphisms and Leukoaraiosis
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전북대학교 의과대학 신경과학교실, 전북대학교 의과학연구소, 전북대학병원 임상의학연구소
- Abstract
- Background
There is an inverse relationship between lesion extent and plasma levels of antioxidants for white-matter
lesions (leukoaraiosis) that are visible on MRI. Paraoxonase (PON) has both antioxidative and antiatherosclerotic
potential, and could thus protect against both macrovascular and microvascular disease. The PON1 gene has two
common polymorphisms in the coding region at positions 192 (Q192R) and 55 (M55L); the PON2 gene also has two
common polymorphisms in the coding region at positions 148 (G148A) and 311 (C311S). We evaluated the associations
between PON polymorphisms and leukoaraiosis, and investigated the role of PON polymorphisms in the lipid profile in
leukoaraiosis.
Methods
A total of 745 subjects was genotyped for the PON1 M55L, PON1 Q192R, PON2 G148A, and PON2 C311S
polymorphisms using melting-point analysis with LightCycler real-time PCR technology. Leukoaraiosis was graded into
absent, punctuate, early confluent, and confluent abnormalities using 1.5-T superconducting magnets with T2-weighted
and fluid-attenuated inversion-recovery sequences.
Results
The severity of leukoaraiosis was correlated with hypertension, advanced age, homocysteine, and serum
C-reactive protein (p<0.05). The genotype and allele distribution of the PON polymorphisms did not differ significantly
between the leukoaraiosis and control subjects. We found that PON1 55 LL genotype was correlated with high serum
concentrations of lipoprotein A (p<0.05). The PON2 148 GG and PON2 311 SS genotypes were correlated with high serum
concentrations of cholesterol, apolipoprotein B, and low-density lipoprotein (p<0.05).
Conclusions
No association was found between PON gene polymorphisms and leukoaraiosis. Leukoaraiosis can be
influenced by the PON1 55 LL, PON2 148 GG, and PON2 311 SS genotypes, which affect the serum concentration of
lipoprotein.Key Words: Leukoaraiosis, Paraoxonase, Polymorphism, Lipoprotein
Keywords :
- 초록
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