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J Korean Neurol Assoc. 2009;27(3):237-242.
- Current Source Analysis of Interictal Spikes in Two Patients With Gelastic Epilepsy-Hypothalamic Hamartoma Syndrome
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Seunguk Jung
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Department of Neurology, Gyeongsang National University School of Medicinea, Jinju, Korea
Gyeongsang Institute of Health Science, Gyeongsang National Universityb, Jinju, Korea
- 홍소발작-시상하부과오종증후군 환자 두 명의
발작간극파 전류원분석
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정승욱, 권오영a,b 정석원a 하은옥a 이수민a 강규식a,b 강희영a,b 박기종a,b 최낙천a,b 임병훈a,b
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경상대학교 의학전문대학원 신경과학교실a, 경상대학교 건강과학연구원b
- Abstract
- Background
Interictal spikes in gelastic epilepsy-hypothalamic hamartoma syndrome are mainly in the fronto-temporal
area. Current source analysis of the interictal spikes has not been done enough. We tried the current source analysis in 2
patients with gelastic epilepsy-hypothalamic hamartoma syndrome using both of the discrete and distributed models.
Methods
Twenty 1 sec epochs including the negative peak of the spikes, were selected from one or two electroencephalographic
recordings respectively in each patient. These 20 epochs were averaged into a single spike. The current
dipole sources of the averaged spike were analyzed and located on a spherical head model. The current source density of
the negative peak point of the averaged spike was located on the Talairach human brain map.
Results
The current dipole sources were in the right subcallosal gyrus, or the right or left anterior cingulate gyri. The
current source density was distributed in the bilateral medial frontal area including the anterior cingulate gyri.
Conclusions
The interictal spikes of patients with gelastic epilepsy-hypothalamic hamartoma syndrome may be
generated by the current sources located in the bilateral medial frontal area. Key Words: Gelastic seizure, Hypothalamic hamartoma, Current source analysis
Keywords :
- 초록
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