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J Korean Neurol Assoc. 2009;27(2):142-146.
- The Effect of Androsterone as the Metabolite of Testosterone to Seizure Suppression
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Won-Joo Kim
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Department of Neurology, College of Medicine, Yonsei University, Seoul, Korea
- 테스토스테론의 대사물인 androsterone의
경련억제에 대한 영향
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김원주, 이수연 조경주 이병인
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연세대학교 의과대학 신경과학교실
- Abstract
- Background
Androsterone is one of the major metabolites from testosterone whose clinical importance remains unclear.
This study evaluated the effects of androsterone on seizure susceptibility in mouse models of epilepsy.
Methods
The efficacy of androsterone (10~200 mg/kg, i.p.) against seizures induced by various GABA receptor
antagonists and glutamate receptor agonists was evaluated.
Results
Androsterone protected mice against seizures induced by PTZ (pentylenetetrazol), PCX (picrotoxin), and
DMCM (methyl-6,7-dimethoxy-4-ethyl-β-carboline-3-carboxylate) in a dose-dependent manner. Androsterone did not
protect against seizures induced by kainic acid, NMDA (N-methyl-D-aspartic acid), or 4-AP (4-aminopyridine) in mice.
Conclusions
These results suggest that androsterone exhibits anticonvulsant activity that occurs largely via nongenomic
mechanisms. Testosterone-derived androsterone might be an endogenous protective neuroactive steroid in the brain. Key Words: Androsterone, GABA, Seizure, Neuroactive steroid
Keywords :
- 초록
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