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J Korean Neurol Assoc. 2009;27(1):49-53.
- Is Antipsychotic Intake a Risk Factor for the Restless Legs Syndrome?
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Hyunwoo Nam
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Departments of Neurology and Psychiatrya, Boramae Hospital, Seoul National University College of Medicine,
Seoul, Korea
- 항정신병제의 복용은 하지불안증후군의 위험 요소인가?
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남현우, 조진환 홍윤호 권형민 차정인 정희연a
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서울대학교 의과대학 보라매병원 신경과, 정신과a
- Abstract
- Background
Restless-legs syndrome (RLS) is known to be caused by dopaminergic hypofunction in the brain. We
investigated whether antipsychotics that act as antidopaminergics increase the risk of RLS.
Methods
We prospectively recruited 72 schizophrenic patients who had been medicated with antipsychotic drugs
in a psychiatry clinic. We evaluated RLS diagnostic criteria and basic sleep habits using the Epworth Sleepiness
Scale and Pittsburgh Sleep Quality Index by face-to-face interviews using a structured questionnaire. We also
applied the Unified Parkinson’s Disease Rating Scale to evaluate extrapyramidal symptoms.
Results
Three of the 72 patients (4.2%) met RLS criteria, which is similar to the previously reported RLS incidence
among the general population in Korea.
Conclusions
There is no evidence that antipsychotics increase the risk of RLS. We believe that the mild antidopaminergic
effect of antipsychotics does not overwhelm their prominent antipsychotic effect. Key Words: Antipsychotic, Schizophrenia, Restless-legs syndrome, Dopaminergic system
Keywords :
- 초록
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