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J Korean Neurol Assoc. 2009;27(1):13-18.
- Change of Serum Neuron Specific Enolase Level During Acute Stage
of Cerebral Infarction
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Bon D. Ku
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Department of Neurology, Kwandong University College of Medicine, Gyeonggi-do, Korea
Department of Neurology, KyungHee University School of Medicinea, Seoul, Korea
- 급성 뇌경색에서 시간 경과에 따른 혈청 신경원 특이
에놀라제(neuron specific enolase)의 변화
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구본대, 정경천a
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관동대학교 의과대학 신경과학교실, 경희대학교 의과대학 신경과학교실a
- Abstract
- Background
Neuron-specific enolase (NSE) is a useful indicator of neuronal injury in acute cerebral infarction.
We investigated the changes in serial serum NSE levels in patients with acute cerebral infarction.
Methods
We measured serial serum NSE levels at 24, 48, 72, and 96 hours, and 2 weeks after the onset of
cerebral infarction in 30 patients (15 territorial and 15 lacunar infarctions). We also measured the NSE levels in
age-matched controls (n=15) who had no evidence of acute stroke or other neurological disorders. The NSE level
was measured using a radioimmunoassay.
Results
The initial serum NSE level was significantly higher in the cerebral infarction group than in the control
group (6.6±2 vs 4.7±1.6 ng/mL [mean±SD], p=0.006). This difference was also observed between the territorial and
lacunar infarction groups until 72 hours after the cerebral infarction. The serum NSE level peaked at 72 hours
after the infarction in both lacunar and territorial infarction groups. The correlation between the NSE level and
the score on the NIH Stroke Scale was strongest at 48 hours after the cerebral infarction (r=0.469).
Conclusions
Serum NSE level can be a good indicator for distinguishing lacunar from territorial infarction during
the acute stage of cerebral infarction. Key Words: Neuron-specific enolase, Acute cerebral infarction
Keywords :
- 초록
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