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J Korean Neurol Assoc. 2008;26(3):224-230.
- The Effect of Acetylcholine Esterase Inhibitor on Cerebrospinal Fluid β-Amyloid 1-42 and Phosphorylated Tau Protein in Korean Alzheimer’s Disease Patients: Preliminary Study
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Eun Hui Lee
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Department of Neurology, College of Medicine, Chung Ang University, Seoul, Korea; Department of Neurologya, Keyo Hospital, Uiwang, Korea; Department of Neurosurgeryb, Suwon woori hospital, Suwon, Korea
- 한국의 알츠하이머병 환자에서 아세틸콜린 에스터레이스 억제제의 뇌척수액 베타아밀로이드 1-42 분획과 인산화타우단백 농도에 미치는 효과
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이은희, 윤영철 박광열 민주홍 권오상 이현옥a 홍현종b
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중앙대학교 의과대학 신경과학교실, 계요병원 신경과a, 수원우리병원 신경외과b
- Abstract
- Background
Alzheimer’s disease (AD) is characterized by the pathology of amyloid plaques and tau-associated neurofibrillary tangles. Acetylcholine esterase (AChE) transforms the β-amyloid monomer into an oligomer, and increases β-amyloid aggregation in the brain. Increased β-amyloid breaks the cytoskeleton of the brain by hyperphosphorylation of the tau protein. Previous studies support that AChE inhibitor has an inhibitory effect on toxicity of the β-amyloid and phophorylated tau protein. The purpose of this study was to analyze the CSF β-amyloid 1-42 (Aβ1-42) and phosphorylated tau protein in AD and determine their difference depending on whether AChE inhibitor was taken or not.
Methods
Subjects included 16 AD, 14 normal controls, and 15 disease controls. Nine of AD group had taken an AChE inhibitor while the remainder had not. The CSF Aβ1-42 and phosphorylated tau were measured by ELISA.
Results
The CSF Aβ1-42 levels were lower in AD patients than in other groups (p<0.01). We also found increased CSF Aβ1-42 levels in the AChE inhibitor users, compared with non-users.
Conclusions
The level of CSF Aβ1-42 may have a diagnostic value in the patients with cognitive impairments. Also, we may expect the effect of AChE inhibitor on Alzheimer’s pathology by measuring CSF Aβ1-42 levels. Therefore, the level of CSF Aβ1-42 may serve as a biological surrogate marker for AD treatment. KeyWords:Alzheimer’s disease, β-Amyloid, Tau protein, Acetylcholine esterase inhibitor
Keywords :
- 초록
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