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J Korean Neurol Assoc. 2006;24(3):210-214.
- The Change of PAC-1 and P-selectin Expression after Initiation of Antiplatelets in Patients with Acute Ischemic Stroke
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Sun Ah Park
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Departments of Neurology and Internal Medicinea, Soonchunhyang University College of Medicine,
Bucheon, Korea
- 급성 뇌경색 환자에서 항혈소판제 투여 후 PAC-1과 P-selectin 발현의 변화
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박선아, 김은영a 하성래 박정호 이태경 성기범 박춘식a
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순천향대학교 의과대학 신경과학교실, 내과학교실a
- Abstract
- Background
The purpose of this study was to evaluate the time course of PAC-1 and the P-selectin expression after the initiation of antiplatelets in acute ischemic stroke.
Methods
We serially measured PAC-1 and the P-selectin expression level using flow cytometry immediately before and at: one day, seven days, and one month after starting antiplatelets in 25 patients with acute cerebral infarctions.
Results
The P-selectin expression increased initially (p<0.05) and then from the seventh day, it began to decrease continually (post-hoc analysis, p<0.05). However, the PAC-1 expression did not reveal significant alterations during the follow-up period of one month.
Conclusions
Although the P-selectin expression rapidly declined, the PAC-1 expression remained elevated for one month. Our results suggest that the P-selectin may be useful in monitoring platelet inhibition during the early period after cerebral infarction.KeyWords:Antiplatelets, Cerebral infarction, Flowcytometry, Platelets
Keywords :
- 초록
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