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J Korean Neurol Assoc. 2006;24(2):148-152.
- A Case of Voltage Gated Potassium Channel Antibodies-associated Nonparaneoplastic Limbic Encephalitis
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Yoseob Won, M.D.
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Departments of Neurology, Nuclear Medicinea, Yonsei University College of Medicine, Seoul, Korea
- 전압의존형칼륨통로 항체와 연관된 비부수종양성 변연계뇌염 1예
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원요섭, 김지윤 박형준 박수철 이종두a 최일생
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연세대학교 의과대학 신경과교실, 핵의학교실a
- Abstract
- Limbic encephalitis has been reported usually as an autoimmune complication related to onconeuronal antigen of underlying cancer with poor prognosis. Antibodies reactive with neuronal voltage-gated potassium channels (VGKCs) are recently recognized as a pathogenic cause in nonparaneoplastic limbic encephalitis, which is responsive to immunotherapy. We report a patient who had subacute encephalopathy with clinical and radiographic evidences of limbic encephalitis. The patient was seropositive for VGKC antibodies and resulted in a good prognosis with steroids. This has not yet been reported in Korea.KeyWords:Nonparaneoplastic limbic encephalitis, Voltage gated potassium channel antibody, Immunotherapy
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