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J Korean Neurol Assoc. 2005;23(1):71-76.
- Clinical and Laboratory Characteristics of Recurrent Optic Neuritis; Comparison with Monophasic Optic Neuritis
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Joong-Seok Kim
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Department of Neurology, The Catholic University of Korea, College of Medicine, Seoul, Korea
- 단상성 시신경염과 비교한 재발성 시신경염의 임상 및 검사실 소견의 특징
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김중석, 박정욱 박성경 정성우 최영빈 김영인 고석범 이광수
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가톨릭대학교 의과대학 신경과학교실
- Abstract
- Background
Although relapses are known to be common in optic neuritis, there are only a few follow-up studies concerning recurrent optic neuritis. The aim of this study is to characterize the difference between monophasic and recurrent optic neuritis by analyzing clinical and laboratory spectrums of index event.
Methods
We performed a partially retrospective and prospective cohort study of patients with optic neuritis. The patients with optic neuritis were included by review of their medical records and neuroimaging studies and then followed up for the relapses of optic neuritis. Excluded were those who showed any evidence of multiple sclerosis, and those with prior demyelinating attacks.
Results
Thirteen of 43 enrolled patients had a recurrent optic neuritis during a mean (SD) follow up period of 58.0 (21.2) months, yielding a 5-year cumulative rate of recurrence of 39.5 percent. The patients who had CSF pleocytosis were more likely to develop a recurrent attacks (P<0.05), but neither clinical findings nor the other laboratory results appeared to influence recurrence.
Conclusions
We suggest that this disorder have a distinctive feature in terms of relapse and CSF pleocytosis compared with monophasic optic neuritis.KeyWords:Optic neuritis, Recurrence, CSF, Pleocytosis
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- 초록
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