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J Korean Neurol Assoc. 2005;23(1):21-27.
- The Change of Cognitive Function and Prognostic Factor in Alzheimer's Disease: 1-Year Follow-up Study
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Tae-You Kim
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Department of Neurology, Gimhae Hansol Hospital, Gimhae;
Department of Neurology, Seoul National University College of Medicine*, Seoul;
Department of Neurology, Hwamyung Hansol Hospital†, Busan;
Department of Neurology, Busan Medical Center‡, Busan;
Department of Neurology, Taebong Hospital§, Masan;
Department of Neurology, Seoul Metropolitan Seodaemun Hospital∥, Seoul;
Department of Psychiatry, Busan Dongin Geriatric Hospital¶, Busan;
Department of Radiology, Catholic University of Korea College of Medicine**, Suwon, Korea
- 알쯔하이머병 환자의 인지기능 변화 및 예후인자: 1년 추적
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김태유, 김상윤* 홍태용† 성상민‡ 윤성민§ 이은아∥ 곽강호¶ 인연권
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김해한솔병원 신경과, 서울대학교 의과대학 신경과학교실*, 부산화명한솔병원 신경과†, 부산의료원 신경과‡,
마산태봉병원 신경과§, 서울특별시립서대문병원 신경과∥, 부산동인노인병원 정신과¶,
가톨릭대학교 의과대학 방사선과학교실**
- Abstract
- Background
The rate of cognitive change and prognostic factor in Alzheimer's disease are important for clinical management, but little is known in Korea. We report a one year follow-up study of comprehensive evaluation including cognitive functions, behavioral and psychological symptoms of dementia (BPSD) and activity of daily living (A이).
Methods
43 patients with Alzheimer's disease were enrolled. All subjects received the Korean version of Mini-Mental State Examination (K-MMSE), the Severe Dementia Scale (SDS), the extended version of Korean Clinical Dementia Rating Scale (CDR) and Sum of Box (CDR-SB), the Barthel index of Activity of Daily Living (B-ADL), the Korean Instrumental Activity of Daily Living (K-IADL) and the Korean version of the Neuropsychiatric Inventory (K-NPI). We retested each scale after 1 year and evaluated the changes.
Results
The mean change rates of K-MMSE, SDS, CDR, CDR-SB and B-ADL scores were 2.0±3.2 (-7~8) mean±SD (range), 3.5±4.9 (-7~14), -0.4±0.7 (-2~1), -0.8±4.4 (-10~9) and 1.5±3.7 (-7~9). The change of K-MMSE and B-ADLscore according to CDR were significantly different. The annual rates of changes of scores on K-MMSE, B-ADL and CDR were largest in CDR 1 group (K-MMSE: 4.0±2.7, B-ADL: 3.4±2.8, CDR: -1±0.7). The change rate of SDS was largest in CDR 4 (7.2±4.3). There were not any significant factors that affected the change of K-MMSE, SDS, B-ADL or CDR.
Conclusions
These results suggest that K-MMSE is sensitive to the early stage and SDS is sensitive to the later stage. The deterioration rate of cognitive function in Alzheimer's disease is large at middle stage. KeyWords:Alzheimer's disease, Dementia, Prognosis, Cognition, Longitudinal study
Keywords :
- 초록
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