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J Korean Neurol Assoc. 2004;22(5):524-528.
- Serial Follow-up of Neuroimaging Findings in a Progression-free Survival Case with Progressive Multifocal Leukoencephalopathy in Nonimmunocompromised Child
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Won Young Doh
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Department of Neurology, Nuclear Medicine*, Pediatrics†, Neuropathology‡, Neurosurgery§,
Yonsei University College of Medicine, Seoul, Korea
- 정상 면역 상태의 소아에서 발생한 진행성다초점백질뇌병증의 신경영상검사 연속 추적 관찰
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도원영, 조양제 박수철 이종두* 김동수† 김태승‡ 선우일남 최중언§
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연세대학교 의과대학 신경과학교실, 핵의학교실*, 소아과학교실†, 병리학교실‡, 신경외과학교실§
- Abstract
- Progressive multifocal leukoencephalopathy (PML) is a demyelination disease caused by opportunistic infection of the ubiquitous, usually nonpathogenic neurotropic papovavirus (JC virus). The virus infects and destroys myelin-producing oligodendrocytes, thereby causing patchy areas of demyelination in the cerebral white matter. It is exclusively a disease of immunosuppressed individuals. We report a case of an immunocompetent child patient with pathologically-proven PML and with a survival over 3 years after diagnosis. Serial follow up of neuroimaging study including brain MRI, MRS, SPECT and PET was obtained. Key Words: Progressive multifocal leukoencephalopathy, Nonimmunocompromised, Longterm-survival
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