- J Korean Neurol Assoc. 2003;21(5):527-533.
- "The Effects of Dopamin D-1 Agonist (SKF-38393) on Expression of Substance-P & Enkephalin mRNA in the Striatum of Hemiparkinsonian Rat Model"
- Seung Hwan Lee
- Deparment of Neurology and Department of Anatomy*, College of Medicine, Korea University
- "도파민 D1 효현제(SKF-38393)가 편측 파킨슨 흰쥐 모델에서 선조체의 Substance-P와 Enkephalin mRNA 발현에 미치는 영향"
- 이승환 , 권도영 유성욱 고성범 박민규 김@현* 박건우 이대희
- 고려대학교 의과대학 신경과학교실, 고려대학교 의과대학 해부학교실
- Abstract
- "Background: The selective D1 dopamine agonist has been known to play a stimulatory role in substance-P synthesis
in the striatum, but its effect on the enkephalin mRNA expression has not been well known in the striatum of unilateral
6-hydroxydopamine(OHDA)-lesioned rat. So we investigated the effect of selective D1 dopaminergic agonist on substance-
P, enkephalin mRNA expression in the striatum with different time interval. Methods: The lesioned rats were
divided into two groups (treated and non-treated). Each group was subdivided according to time course after lesioning
(2nd, 4th and 8th week). Dopamine 1 receptor agonist, SKF-38393 (5 mg/kg/ip) and the same volume of saline was
injected to treated and nontreated group respectively. The levels of enkephalin and substance-P mRNA were determined
by in situ-hydridization and the expression of mRNA levels were compared between the groups. Results: The expression
of striatal enkephalin mRNA was increased on lesioned side in all groups. Especially, SKF-38393 enhanced the
striatal expression of enkephalin mRNA after lesioning 2nd week. After lesioning 4th week and 8th week, the effect of
SKF-38393 was not significant. The striatal expression of substance-P mRNAs was significantly decreased on the
lesioned side, especially at the 2nd weeks. This decrement of substance-P mRNA was reversed by SKF-38393 at the 2nd
week. Conclusions: These data show that the selective D1 agonist SKF-38393 have an agonistic effect on direct pathway
but antagonistic effect on indirect pathway in early course of Parkinsonian rat model.Key Words: Parkinson rat model, Enkephalin, Substance-P, SKF-38393"
Keywords :