- J Korean Neurol Assoc. 2003;21(4):387-391.
- "Protective Effects of the Green Tea Polyphenol(-)-epigallocatechin Gallate Against Ischemia Reperfusion Injury Induced by Middle Cerebral Artery Occlusion in Rats"
- Young-Bin Choi
- Department of Neurology, College of Medicine, The Catholic University of Korea
- "일시적 국소허혈에 의해 유발된 흰쥐 대뇌 신경세포 손상에 대한 EGCG(epigallocatechin gallate)의 신경보호 효과"
- 최영빈 , 박정욱 한시령 이광수 김범생
- 가톨릭대학교 의과대학 신경과학교실
- Abstract
- "Background: EGCG(epigallocatechin gallate), a major green tea extract, is a potent free radical scavenger which has
been shown to reduce free radical-induced lipid peroxidation. The purpose of this study was to examine whether EGCG
reduces focal ischemia/reperfusion-induced brain injury in rats. Methods: Male Wistar rats were anesthetized with ketamine
and xylazine and subjected to 120 min of temporary middle cerebral artery occlusion by an intraluminal nylon
suture coated with poly-L-lysine. The drug (EGCG, n=8) or vehicle (normal saline, n=8) was administered iv.(as a 50
mg/kg bolus) immediately after the onset of middle cerebral artery occlusion. Neurologic status was evaluated 2 hours
after occlusion and 24 hours after. Twenty-four hours after ischemia, the brain was perfusion-fixated and the infarct volume
was determined. Results: EGCG significantly improved the neurological status at 24 hours after middle cerebral
artery occlusion.(p<0.05), and reduced total infarct volumes (p<0.01). Conclusions: These results demonstrate the neuroprotective
effect of EGCG in a rat model of transient focal cerebral ischemia. Key Words: EGCG, Ischemia, Rat"
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