- J Korean Neurol Assoc. 2003;21(4):334-338.
- "The Serial Change of Platelet Activation for 90 Days in Patients with Atherosclerotic Ischemic Stroke"
- Min-Jeong Park
- Department of Neurology, College of Medicine, Dong-A University
- 동맥경화성 뇌경색 환자들에서 90일간의 혈소판 활성도의 연속적 변화
- 박민정 , 오영미 박경원 차재관 김상호 김재우
- 동아대학교 의과대학 신경과학교실
- Abstract
- "Background: Platelet activation is an important process of atherothrombosis. However, there are few studies demonstrating
the serial changes of platelet activation and the influences of the kinds of therapeutic strategies in atherosclerotic
ischemic stroke from acute onset to the subacute phase. Methods: We serially measured the expressions of CD63 on
platelets in patients with atherosclerotic ischemic stroke (n=29) and compared them with normal subjects (n=52) and
analyzed the effects to reduce the platelet activation according to the therapeutic strategies. Results: The platelet CD63
expression (p<0.001) in atherosclerotic ischemic stroke significantly increased at 24 hours of ischemic stroke onset
compared to normal subjects and their increment continually remained until 90 days after the ischemic events. Among
the 29 patients, 12 patients treated with clopidogrel and aspirin showed significant decreases of the platelet CD63
expression (p=0.01) at 7 days compared to that at 24 hours. However, the reducing effect of this combination regimen
disappeared after 90 days. Conclusions: These results suggest that the hyperexpression of CD63 on platelets in atherosclerotic
ischemic stroke is not easily suppressed by regular anti-platelet medications.Key Words: Blood platelets, Brain ischemia, Cerehral infarction, Inflammation"
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