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J Korean Neurol Assoc. 2003;21(3):283-288.
- "The Effect of Nitric Oxide on Mechanical and Theraml Allodynia in
Neuropathic Pain Model of Rat"
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Sung Hun Kim
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Department of Neurology and Physiology*, College of Medicine, Kangwon National University
- "신경병성 통증의 흰쥐 모델에서 기계적 및 열적 이질통에 대한
Nitric Oxide의 효과"
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김성훈 , 정승준
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강원대학교 의과대학 신경과학교실,생리학교실
- Abstract
- "Background: Nitric oxide (NO) is known to play causative role in the development of neuropathic pain following
peripheral nerve injury. However, it is yet to be investigated whether the role of NO differs in pain modalities, such as
mechanical and thermal stimuli. Also, it has not been investigated whether NO has different roles in the stages of neuro-pathic
pain - its development and maintenance. Methods: Neuropathic pain was induced by a resection of the lumbar
dorsal root 5, 6 (L 5, 6). After N-nitro-L-arginine methyl ester (L-NAME), an NO synthase inhibitor was injected
intrathecally or locally around the dorsal root, we observed the behavioral response to the mechanical and thermal stim-uli.
R e s u l t s: Mechanical and thermal allodynia was inhibited by the application of L-NAME before the dorsal root
injury. However, L-NAME did not affect the mechanical and thermal allodynia during the maintenance of neuropathic
pain. Conclusions: We suggest that NO in the spinal cord or injured perineural site may play an important role in the
induction of neuropathic pain, and may be associated with mechanical and thermal allodynia.Key Words: Nitric oxide, Neuropathic pain, Nitric oxide synthase, Mechanical stimuli, Thermal stimuli"
Keywords :
- 초록
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