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J Korean Neurol Assoc. 2003;21(3):248-254.
- "Predictive Value of C-Reactive Protein in the Differential
Diagnosis of Acute Meningitis in Adults"
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Jeong-Wook Park
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Department of Neurology, College of Medicine, The Catholic University of Korea
- 성인 뇌수막염의 감별 진단에서 C-Reactive Protein의 예측적 의의
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박정욱 , 정성우 고석범 최영빈 이광수
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가톨릭대학교 의과대학 신경과학교실
- Abstract
- "Background: The aim of this study was to clarify to what extent bacterial meningitis could be distinguished from
aseptic or tuberculous meningitis through C-reactive protein (CRP) in adults. Methods: We retrospectively analyzed the
medical records of 91 patients aged 15~81 years who had been hospitalized for acute meningitis and underwent lumbar
puncture due to suspected central nervous system infection. Results: We included 50 patients with aseptic meningitis,
23 patients with acute bacterial meningitis, and 18 patients with tuberculous meningitis. Blood CRP was higher in bac-terial
meningitis. None of the patients with bacterial meningitis had a CRP value of under 20 mg/dl. The CRP values
were under 20 mg/dl in 92% of the patients with aseptic meningitis and in 73% of those with tuberculous meningitis.
Taking a CRP level of above 20 mg/dl as a positive discriminatory factor for bacterial meningitis, the sensitivity and
specificity were 1.0, 0.88. To better predict whether a patient has bacterial or nonbacterial meningitis, we developed a
canonical discriminant function equation using CRP and CSF parameter, and finally concluded that blood CRP was a
good predictive indicator that differentiated bacterial meningitis from aseptic or tuberculous meningitis at admission.
C o n c l u s I o n s: The CRP measurement, is easily performed and inexpensive. We believe it is worth analyzing CRP
whenever meningitis is suspected, it can also limit the unnecessary use of antibiotics.Key Words: Meningitis, C-reactive protein, Cerebrospinal fluid, Discriminant analysis"
Keywords :
- 초록
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